Human Interleukin 33, IL-33 ELISA Kit

SKU: E0044Hu

Size:96 Tests-1 Kit

Background:Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed: 16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed: 17853410, PubMed: 18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed: 21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed: 18787100).

Research_area:Cardiovascular; Immunology

Applications:ELISA

Target_protein:IL33

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.36ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin 33

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O95760

MASS(Da):30,759

GeneID:90865

Synonyms:109-270;95-270;99-270;IL 33;IL-1F11;IL33;IL-33;Interleukin-1 family member 11;Interleukin-33;NF-HEV;Nuclear factor from high endothelial venules

Gene names:IL33

Standard solution:2400ng/L