Human Interferon-induced Protein with Tetratricopeptide Repeats 2, IFIT2 ELISA Kit

SKU: E3973Hu

Size:96 Tests-1 Kit

Background:IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.

Research_area:Immunology

Applications:ELISA

Target_protein:IFIT2

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.58ng/L

Detection range:5-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interferon-induced protein with tetratricopeptide repeats 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P09913

MASS(Da):54,632

GeneID:3433

Synonyms:cig42;G10P2;GARG-39;IFI54;IFI-54;IFI-54K;IFIT2;IFIT-2;Interferon-induced 54 kDa protein;Interferon-induced protein with tetratricopeptide repeats 2;ISG54;ISG-54;ISG-54 K;ISG-54K;P54

Gene names:IFIT2

Standard solution:2400ng/L