Human Inhibitor of Growth Protein 4, ING4 ELISA Kit

SKU: E5465Hu

Size:96 Tests-1 Kit

Background:Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed: 16387653). Through chromatin acetylation it may function in DNA replication (PubMed: 16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed: 15251430, PubMed: 15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed: 15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed: 15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed: 15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).

Research_area:Cancer

Applications:ELISA

Target_protein:ING4

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.82ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Inhibitor of Growth Protein 4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UNL4

MASS(Da):28,530

GeneID:51147

Synonyms:ING 4;ING4;Inhibitor of growth protein 4;p29ING4

Gene names:ING4

Standard solution:6400ng/L