Human Hla Class 2 Histocompatibility Antigen Gamma Chain, CD74 ELISA Kit

SKU: E4489Hu

Size:96 Tests-1 Kit

Background:Plays a critical role in MHC class II antigen processing by stabilizing Peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic Peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. [Class-II-associated invariant chain Peptide]: Binds to the Peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic Peptides to the MHC class II complex until its release by HLA-DM in the endosome. [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed: 32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed: 32855215).

Research_area:Immunology

Applications:ELISA

Target_protein:CD74

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.27ng/ml

Detection range:0.5-100ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Hla Class 2 Histocompatibility Antigen Gamma Chain

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P04233

MASS(Da):33,516

GeneID:972

Synonyms:CD 74;CD antigen CD74;CD74;Class-II-associated invariant chain Peptide;CLIP;HLA class II histocompatibility antigen gamma chain;HLA-DR antigens-associated invariant chain;Ia antigen-associated invariant chain;Ii;

Gene names:CD74

Standard solution:128ng/ml