Human Heparan sulfate proteoglycan 2,HSPG2 ELISA KIT

SKU: E5388Hu

Size:96 Tests-1 Kit

Background:Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.; Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.; The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.

Research_area:

Applications:ELISA

Target_protein:HSPG2

Reactivity:Human

Assay type:Sandwich

Sensitivity:16.15ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Heparan sulfate proteoglycan 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P98160

MASS(Da):468830

GeneID:3339

Synonyms:HSPG2

Gene names:HSPG2

Standard solution:9600ng/L