Human Glycyl Trna Synthetase, GARS ELISA Kit

SKU: E2239Hu

Size:96 Tests-1 Kit

Background:Acyl-CoA synthetase that catalyzes the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed: 107$498.00|$360.0048, PubMed: 11980911). Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (PubMed: 107$498.00|$360.0048, PubMed: 11980911). Also exhibits acyl CoA synthetase activity that activates very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (PubMed: 10479480). In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed: 11980911). Exhibits long-chain fatty acids (LCFA) transport activity (PubMed: 20530735). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity).

Research_area:Cardiovascular

Applications:ELISA

Target_protein:SLC27A5

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.03ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Glycyl Trna Synthetase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y2P5

MASS(Da):75,385

GeneID:10998

Synonyms:BA-CoA ligase;BACS;BAL;Bile acid-CoA ligase;Bile acyl-CoA synthetase;Cholate--CoA ligase;FATP-5;Fatty acid transport protein 5;Fatty-acid-coenzyme A ligase, very long-chain 3;SLC27A5;Solute carrier family 27 member 5;Very long-chain acyl-CoA synthetase homolog 2;Very long-chain acyl-CoA synthetase-related protein;VLACSR;VLACS-related;VLCSH2;VLCS-H2

Gene names:SLC27A5

Standard solution:4800ng/L