Human Gem-associated Protein 6, GEMIN6 ELISA Kit

SKU: E5325Hu

Size:96 Tests-1 Kit

Background:The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

Research_area:Others

Applications:ELISA

Target_protein:GEMIN6

Reactivity:Human

Assay type:Sandwich

Sensitivity:6.97ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Gem-Associated Protein 6

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8WXD5

MASS(Da):18,824

GeneID:79833

Synonyms:Gem-associated protein 6;GEMIN 6;GEMIN6;Gemin-6;SIP2

Gene names:GEMIN6

Standard solution:3200ng/L