Human Gamma-glutamyltranspeptidase 1,GGT1 ELISA KIT

SKU: E7146Hu

Size:96 Tests-1 Kit

Background:Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates and other gamma-glutamyl compounds, such as leukotriene C4 (LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:17924658, PubMed:7673200, PubMed:7759490, PubMed:8095045, PubMed:8827453, PubMed:21447318). Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4. {ECO:0000269|PubMed:17924658, ECO:0000269|PubMed:20622017, ECO:0000269|PubMed:21447318, ECO:0000269|PubMed:24047895, ECO:0000269|PubMed:7673200, ECO:0000269|PubMed:7759490, ECO:0000269|PubMed:8095045, ECO:0000269|PubMed:8827453}.; [Isoform 3]: Seems to be inactive. {ECO:0000269|PubMed:7689219}.

Research_area:

Applications:ELISA

Target_protein:GGT1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.95ng/ml

Detection range:1.88-120ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:human Gamma-glutamyltransferase 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P19440

MASS(Da):61410

GeneID:2678

Synonyms:GGT1 GGT

Gene names:GGT1

Standard solution:240ng/ml