Human G protein-coupled receptor 109A,GPR109A ELISA KIT

SKU: E0689Hu

Size:96 Tests-1 Kit

Background:Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. {ECO:0000269|PubMed:17932499}.

Research_area:

Applications:ELISA

Target_protein:HCAR2

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.41ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:G protein-coupled receptor 109A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8TDS4

MASS(Da):41850

GeneID:338442

Synonyms:HCAR2 GPR109A HCA2 HM74A NIACR1

Gene names:HCAR2

Standard solution:1600ng/L