Human Frizzled-2, FZD2 ELISA Kit

SKU: E2369Hu

Size:96 Tests-1 Kit

Background:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed: 25759469). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium (PubMed: 27680706, PubMed: 29748286). TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling (PubMed: 29748286).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:FZD2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.013ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Frizzled-2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q14332

MASS(Da):63,554

GeneID:2535

Synonyms:Frizzled-2;Fz-2;FZD 2;FZD2;FzE2;hFz2

Gene names:FZD2

Standard solution:12.8ng/ml