Human fragile histidine triad,FHIT ELISA KIT

SKU: E5305Hu

Size:96 Tests-1 Kit

Background:Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor. {ECO:0000269|PubMed:12574506, ECO:0000269|PubMed:15313915, ECO:0000269|PubMed:16407838, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:19622739, ECO:0000269|PubMed:8794732, ECO:0000269|PubMed:9323207}.

Research_area:

Applications:ELISA

Target_protein:FHIT

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.72ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:fragile histidine triad

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P49789

MASS(Da):16858

GeneID:2272

Synonyms:FHIT

Gene names:FHIT

Standard solution:4800ng/L