Human Fibroblast Growth Factor Receptor 3, FGFR3 ELISA Kit

SKU: E5290Hu

Size:96 Tests-1 Kit

Background:Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:FGFR3

Reactivity:Human

Assay type:Sandwich

Sensitivity:14.93ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Fibroblast Growth Factor Receptor 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P22607

MASS(Da):87,710

GeneID:2261

Synonyms:CD antigen CD333;FGFR 3;FGFR3;FGFR-3;Fibroblast growth factor receptor 3

Gene names:FGFR3

Standard solution:9600ng/L