Human Exportin 1, XPO1 ELISA Kit

SKU: E2694Hu

Size:96 Tests-1 Kit

Background:Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

Research_area:Others

Applications:ELISA

Target_protein:XPO1

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.28ng/L

Detection range:20-3800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Exportin 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O14980

MASS(Da):123,386

GeneID:7514

Synonyms:Chromosome region maintenance 1 protein homolog;Exp1;Exportin-1;XPO 1;XPO1

Gene names:XPO1

Standard solution:4000ng/L