Human Eukaryotic Translation Initiation Factor 4E-binding Protein 1, EIF4EBP1 ELISA Kit

SKU: E5268Hu

Size:96 Tests-1 Kit

Background:Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:EIF4EBP1

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.09ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Eukaryotic translation initiation factor 4E-binding protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13541

MASS(Da):12,580

GeneID:1978

Synonyms:4EBP1;4E-BP1;BP-1;eIF4E-binding protein 1;EIF4EBP1;Eukaryotic translation initiation factor 4E-binding protein 1;PHAS-I;Phosphorylated heat- and acid-stable protein regulated by insulin 1

Gene names:EIF4EBP1

Standard solution:6400ng/L