Human Ephrin-A1, EFNA1 ELISA Kit

SKU: E5253Hu

Size:96 Tests-1 Kit

Background:Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

Research_area:Cardiovascular

Applications:ELISA

Target_protein:EFNA1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.024ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Ephrin-A1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P20827

MASS(Da):23,787

GeneID:1942

Synonyms:EFNA 1;EFNA1;EPH-related receptor tyrosine kinase ligand 1;Ephrin-A1;Ephrin-A1, secreted form;Immediate early response protein B61;LERK-1;TNF alpha-induced protein 4;Tumor necrosis factor alpha-induced protein 4;

Gene names:EFNA1

Standard solution:24ng/ml