Human Endoribonuclease Dicer,DICER1 ELISA KIT

SKU: E4292hu

Size:96 Tests-1 Kit

Background:Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}.

Research_area:

Applications:ELISA

Target_protein:DICER1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.14ng/ml

Detection range:0.3-90ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Endoribonuclease Dicer

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UPY3

MASS(Da):218682

GeneID:23405

Synonyms:DICER1 DICER HERNA KIAA0928

Gene names:DICER1

Standard solution:96ng/ml