Human Elongation of very long chain fatty acids protein 1,ELOVL1 ELISA KIT

SKU: E7520Hu

Size:96 Tests-1 Kit

Background:Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:29496980, PubMed:30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis (PubMed:20937905). Indirectly inhibits RPE65 via production of VLCFAs. {ECO:0000255|HAMAP-Rule:MF_03201, ECO:0000269|PubMed:20166112, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:29496980, ECO:0000269|PubMed:30487246}.

Research_area:

Applications:ELISA

Target_protein:ELOVL1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.2ng/ml

Detection range:0.38-24ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9BW60

MASS(Da):32663

GeneID:64834

Synonyms:ELOVL1 SSC1 CGI-88

Gene names:ELOVL1

Standard solution:48ng/ml