Human E3 ubiquitin-protein ligase TRIM56,TRIM56 ELISA KIT

SKU: E7470Hu

Size:96 Tests-1 Kit

Background:E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160). {ECO:0000250|UniProtKB:Q80VI1, ECO:0000269|PubMed:21289118, ECO:0000269|PubMed:22948160}.

Research_area:

Applications:ELISA

Target_protein:TRIM56

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.19ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:E3 ubiquitin-protein ligase TRIM56

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9BRZ2

MASS(Da):81488

GeneID:81844

Synonyms:TRIM56 RNF109

Gene names:TRIM56

Standard solution:2400ng/L