Human E3 Ubiquitin-protein Ligase Smurf1, SMURF1 ELISA Kit

SKU: E6630Hu

Size:96 Tests-1 Kit

Background:E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Research_area:Cell Biology

Applications:ELISA

Target_protein:SMURF1

Reactivity:Human

Assay type:Sandwich

Sensitivity:12.28ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:E3 ubiquitin-protein ligase SMURF1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9HCE7

MASS(Da):86,114

GeneID:57154

Synonyms:E3 ubiquitin-protein ligase SMURF1;HECT-type E3 ubiquitin transferase SMURF1;hSMURF1;SMAD ubiquitination regulatory factor 1;SMAD-specific E3 ubiquitin-protein ligase 1;SMURF1

Gene names:SMURF1

Standard solution:4800ng/L