Human DNA (cytosine-5)-methyltransferase 3A,DNMT3A ELISA KIT

SKU: E7364Hu

Size:96 Tests-1 Kit

Background:Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). {ECO:0000250|UniProtKB:O88508, ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}.

Research_area:

Applications:ELISA

Target_protein:DNMT3A

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.044ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:DNA Methyltransferase 3A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y6K1

MASS(Da):101858

GeneID:1788

Synonyms:DNMT3A

Gene names:DNMT3A

Standard solution:48ng/ml