Human DNA-binding Protein Inhibitor Id-2, ID2 ELISA Kit

SKU: E5199Hu

Size:96 Tests-1 Kit

Background:Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:ID2

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.48ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:DNA-Binding Protein Inhibitor ID-2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q02363

MASS(Da):14,917

GeneID:3398

Synonyms:bHLHb26;Class B basic helix-loop-helix protein 26;DNA-binding protein inhibitor ID-2;ID 2;ID2;Inhibitor of differentiation 2;Inhibitor of DNA binding 2

Gene names:ID2

Standard solution:3200ng/L