Human DNA-binding Protein Ikaros, IKZF1 ELISA Kit

SKU: E5197Hu

Size:96 Tests-1 Kit

Background:Transcription regulator of hematopoietic cell differentiation (PubMed: 17934067). Binds gamma-satellite DNA (PubMed: 17135265, PubMed: 19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed: 17135265, PubMed: 17934067).

Research_area:Others

Applications:ELISA

Target_protein:IKZF1

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.06ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:DNA-Binding Protein Ikaros

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13422

MASS(Da):57,528

GeneID:10320

Synonyms:DNA-binding protein Ikaros;Ikaros family zinc finger protein 1;IKZF 1;IKZF1;Lymphoid transcription factor LyF-1

Gene names:IKZF1

Standard solution:4800ng/L