Human Disrupted In Schizophrenia 1 Protein, DISC1 ELISA Kit

SKU: E3918Hu

Size:96 Tests-1 Kit

Background:Disrupted in schizophrenia 1 is a protein that in humans is encoded by the DISC1 gene. In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the regulation of cell proliferation, differentiation, migration, neuronal axon and dendrite outgrowth, mitochondrial transport, fission and/or fusion, and cell-to-cell adhesion. Several studies have shown that unregulated expression or altered protein structure of DISC1 may predispose individuals to the development of schizophrenia, clinical depression, bipolar disorder, and other psychiatric conditions. The cellular functions that are disrupted by permutations in DISC1, which lead to the development of these disorders, have yet to be clearly defined and are the subject of current ongoing research. Although, recent genetic studies of large schizophrenia cohorts have failed to implicate DISC1 as a risk gene at the gene level, the DISC1 interactome gene set was associated with schizophrenia, showing evidence from genome-wide association studies of the role of DISC1 and interacting partners in schizophrenia susceptibility.

Research_area:Neuroscience

Applications:ELISA

Target_protein:DISC1

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.22ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Disrupted in schizophrenia 1 protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NRI5

MASS(Da):93,611

GeneID:27185

Synonyms:C1orf136;DISC1;Disrupted in schizophrenia 1 protein;SCZD9

Gene names:DISC1

Standard solution:6400ng/L