Human Disintegrin and metalloproteinase domain-containing protein 17,ADAM17 ELISA KIT

SKU: E4754Hu

Size:96 Tests-1 Kit

Background:Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:9034191}.

Research_area:

Applications:ELISA

Target_protein:ADAM17

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.098ng/ml

Detection range:0.2-50ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:A Disintegrin And Metalloprotease 17

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P78536

MASS(Da):93021

GeneID:6868

Synonyms:ADAM17 CSVP TACE

Gene names:ADAM17

Standard solution:56ng/ml