Human Discs, Large Homolog 4, DLG4 ELISA Kit

SKU: E2657Hu

Size:96 Tests-1 Kit

Background:Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium Channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the Channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the Channels in an activated state in the presence of glutamate and preventing synaptic depression.

Research_area:Neuroscience

Applications:ELISA

Target_protein:DLG4

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.05ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Discs, Large Homolog 4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P78352

MASS(Da):80,495

GeneID:1742

Synonyms:Disks large homolog 4;DLG 4;DLG4;Postsynaptic density protein 95;PSD-95;SAP90;SAP-90;Synapse-associated protein 90

Gene names:DLG4

Standard solution:48ng/ml