Human DAND5/COCO ELISA Kit PicoKine®

SKU: EK1658

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: DAND5

Specificity: Natural and recombinant human DAND5

Background: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: R23-A189

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Reference:

Uniprot ID: Q8N907

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 199699

Protein Name: DAN domain family member 5

Gene Full Name: DAN domain BMP antagonist family member 5

Synonyms: CER2; Cerberus like protein 2; Cerl 2; CERL2; CKTSF1B3; COCO; CRL2; DAN domain family member 5; DAN domain family; member 5; DAND5; DANTE; GREM3; Gremlin 3; SP1