Human Cystatin M/Cystatin E/CST6 ELISA Kit PicoKine®

SKU: EK1965

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: CST6

Specificity: Natural and recombinant human Cystatin m/CST6

Background: Cystatin-M is a protein that in humans is encoded by the CST6 gene. It is mapped to 11q13.1. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: R29-M149

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Reference:

Uniprot ID: Q15828

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 1474

Protein Name: Cystatin-M

Gene Full Name: cystatin E/M

Synonyms: CST6; Cystatin 6; Cystatin E; cystatin E/M; Cystatin M