Human Cystatin C ELISA Kit EZ-Set™ (DIY Antibody Pairs)

SKU: EZ0678

Size: 5 plates/kit

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: CST3

Specificity: Natural and recombinant human IL-32

Background: Cystatin C or cystatin 3 (formerly gamma trace, post-gamma-globulin or neuroendocrine basic polypeptide), a protein encoded by the CST3 gene, was originally described as a constituent of normal cerebrospinal fluid (CSF) and of urine from patients with renal failure.1 Cystatin 3 has a low molecular weight (approximately 13.3 kilodaltons), and it is removed from the bloodstream by glomerular filtration in the kidneys. In humans, all cells with a nucleus (cell core containing the DNA) produce cystatin C as a chain of 120 amino acids. It is found in virtually all tissues and bodily fluids. Cystatin C, which belongs to the type II cystatin gene family, is a potent inhibitor of lysosomal proteinases2 (enzymes from a special subunit of the cell that break down proteins) and probably one of the most important extracellular inhibitors of cysteine proteases3 (it prevents the breakdown of proteins outside the cell by a specific type of protein degrading enzymes). Moreover, cystatin C is involved in network reorganization in the epileptic dentate gyrus.4

Immunogen: Expression system for standard: NS0; Immunogen sequence: M1-A146

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Reference:

Uniprot ID: P01034

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 1471

Protein Name: Cystatin-C

Gene Full Name: cystatin C

Synonyms: ARMD11; CST3; Cystatin 3; cystatin C; CYTC; Gamma trace; Post gamma globulin