Human Cystatin B/CSTB ELISA Kit PicoKine®

SKU: EK1205

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: CSTB

Specificity: Natural and recombinant human Cystatin B

Background: Cystatin B (CSTB), also called STFB, is a small protein that is a member of the superfamily of cysteine protease inhibitors. It has been isolated from human spleen and liver and its amino acid sequence has been fully determined. The cystatin B gene is located on 21q22.3. It is widely distributed and is localized mostly intracellularly, but has been found extracellularly. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Its role is thought to be as a protector against the proteinases leaking from lysosomes. A cystatin B multiprotein complex might have a specific cerebellar function, and that the loss of this function might contribute to the etiopathogenesis of EPM1. Upon differentiation to myotubes, CSTB becomes excluded from the nucleus and lysosomes, suggesting that the subcellular distribution of CSTB is dependent on the differentiation status of the cell.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: M2-F98

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Reference:

Uniprot ID: P04080

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 1476

Protein Name: Cystatin-B

Gene Full Name: cystatin B

Synonyms: CPI B; CST6; CSTB; Cystatin B; cystatin B (stefin B); EPM1; PME; Stefin B; STFB