Human Cyclin-dependent Kinase Inhibitor 1, CDKN1A ELISA Kit

SKU: E3243Hu

Size:96 Tests-1 Kit

Background:May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed: 11595739). Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed: 9106657).

Research_area:Others

Applications:ELISA

Target_protein:CDKN1A

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.94ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cyclin-Dependent Kinase Inhibitor 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P38936

MASS(Da):18,119

GeneID:1026

Synonyms:CDK-interacting protein 1;CDKN1A;Cyclin-dependent kinase inhibitor 1;MDA-6;Melanoma differentiation-associated protein 6;p21

Gene names:CDKN1A

Standard solution:4800ng/L