Human CXCL16 PicoKine® Quick ELISA Kit

SKU: FEK0741

Size: 96 wells/kit, with removable strips.

Storage: Store at 4°C for 6 months. (Ships with gel ice, can store for up to 3 days in room temperature. Refrigerate upon receipt.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: CXCL16

Specificity: Natural and recombinant human CXCL16

Background: Chemokine (C-X-C motif) ligand 16 (CXCL16) is a small cytokine belonging to the CXC chemokine family. Larger than other chemokines (with 254 amino acids), CXCL16 is composed of a CXC chemokine domain, a mucin-like stalk, a transmembrane domain and a cytoplasmic tail containing a potential tyrosine phosphorylation site that may bind SH2. These are unusual features for a chemokine, and allow CXCL16 to be expressed as a cell surface bound molecule, as well as a soluble chemokine. CXCL16 is produced by dendritic cells found in the T cell zones of lymphoid organs, and by cells found in the red pulp of the spleen. Cells that bind and migrate in response to CXCL16 include several subsets of T cells, and natural killer T (NKT) cells. CXCL16 interacts with the chemokine receptorCXCR6, also known as Bonzo. The novel CXC-chemokine ligand 16 (CXCL16) functions as transmembrane adhesion molecule on the surface of APCs and as a soluble chemoattractant for activated T cells. Expression of CXCL16 is induced by the inflammatory cytokines IFN-gamma and TNF-alpha. The gene for human CXCL16 is located on chromosome 17.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: N49-P137

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Uniprot ID: Q9H2A7

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 58191

Protein Name: C-X-C motif chemokine 16

Gene Full Name: C-X-C motif chemokine ligand 16

Synonyms: C X C motif chemokine 16; CXCL16; CXCLG16; SCYB16; Small inducible cytokine B16; SR PSOX; SRPSOX; Transmembrane chemokine CXCL16