Human CRLF2/TSLP R ELISA Kit PicoKine®

SKU: EK1288

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: CRLF2

Specificity: Natural and recombinant human CRLF2

Background: Cytokine receptor-like factor 2, also known as TSLPR or CRL2, is a protein that in humans is encoded by the CRLF2 gene. It is mapped to Xp22.33. The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. In addition to it, it has been found that rearrangement of CRLF2 and JAK mutation together contribute to leukemogenesis in B-progenitor ALL.

Immunogen: Expression system for standard: NS0; Immunogen sequence: G25-K231

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Reference:

Uniprot ID: Q9HC73

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 64109

Protein Name: Cytokine receptor-like factor 2

Gene Full Name: cytokine receptor like factor 2

Synonyms: cytokine receptor like factor 2; CRL2Y; TSLPR; CRLF2