Human Complement Receptor 1;Erythrocyte,CR1 ELISA KIT

SKU: E3536Hu

Size:96 Tests-1 Kit

Background:Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728). {ECO:0000269|PubMed:25742728, ECO:0000269|PubMed:2963069, ECO:0000269|PubMed:2972794, ECO:0000269|PubMed:8175757}.; (Microbial infection) Acts as a receptor for Epstein-Barr virus. {ECO:0000269|PubMed:23416052}.

Research_area:

Applications:ELISA

Target_protein:CR1

Reactivity:Human

Assay type:Sandwich

Sensitivity:15.27ng/L

Detection range:31.25-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Complement Receptor 1;Erythrocyte

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P17927

MASS(Da):223663

GeneID:1378

Synonyms:CR1 C3BR

Gene names:CR1

Standard solution:4000ng/L