Human Coiled-Coil Domain-containing Protein 134, CCDC134 ELISA Kit

SKU: E5064Hu

Size:96 Tests-1 Kit

Background:In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed: 25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed: 25125657). May inhibit ERK and JNK signaling activity (PubMed: 18087676, PubMed: 23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed: 23070808). In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.

Research_area:Others

Applications:ELISA

Target_protein:CCDC134

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.021ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Coiled-Coil Domain-Containing Protein 134

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9H6E4

MASS(Da):26,561

GeneID:79879

Synonyms:CCDC 134;CCDC134;Coiled-coil domain-containing protein 134

Gene names:CCDC134

Standard solution:24ng/ml