Human Chromodomain-helicase-DNA-binding protein 8,CHD8 ELISA KIT

SKU: E7232Hu

Size:96 Tests-1 Kit

Background:DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692}.

Research_area:

Applications:ELISA

Target_protein:CHD8

Reactivity:Human

Assay type:Sandwich

Sensitivity:26.48ng/L

Detection range:50-3200ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9HCK8

MASS(Da):290519

GeneID:57680

Synonyms:CHD8 HELSNF1 KIAA1564

Gene names:CHD8

Standard solution:6400ng/L