Human Cdk5 Regulatory Subunit-associated Protein 2, CDK5RAP2 ELISA Kit

SKU: E5025Hu

Size:96 Tests-1 Kit

Background:Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PubMed:26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity).

Research_area:Cell Biology

Applications:ELISA

Target_protein:CDK5RAP2

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.19ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:CDK5 regulatory subunit-associated protein 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q96SN8

MASS(Da):215,038

GeneID:55755

Synonyms:C48;CDK5 activator-binding protein C48;CDK5 regulatory subunit-associated protein 2;CDK5RAP2;Centrosome-associated protein 215;Cep215;MCPH3

Gene names:CDK5RAP2

Standard solution:2400ng/L