Human CCN family member 1,CCN1 ELISA KIT

SKU: E5146Hu

Size:96 Tests-1 Kit

Background:Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}.

Research_area:

Applications:ELISA

Target_protein:CCN1

Reactivity:Human

Assay type:Sandwich

Sensitivity:14.35ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cysteine-rich 61

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O00622

MASS(Da):42027

GeneID:3491

Synonyms:CCN1 CYR61 GIG1 IGFBP10

Gene names:CCN1

Standard solution:9600ng/L