Human CASPR2 ELISA Kit PicoKine®

SKU: EK2169

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: CNTNAP2

Specificity: Natural and recombinant Human CASPR2

Background: Contactin-associated protein-like 2 is a protein that in humans is encoded by the CNTNAP2 gene. This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is ly bound and regulated by forkhead box protein P2, a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and intellectual disability.

Immunogen: Expression system for standard: NS0; Immunogen sequence: P29-A1262

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Reference:

Uniprot ID: Q9UHC6

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 26047

Protein Name: Contactin-associated protein-like 2

Gene Full Name: contactin associated protein 2

Synonyms: AUTS15; CASPR2; CDFE; CNTNAP2; KIAA0868; NRXN4