Human Caspase Recruitment Domain-containing Protein 9, CARD9 ELISA Kit

SKU: E4992Hu

Size:96 Tests-1 Kit

Background:Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.

Research_area:Others

Applications:ELISA

Target_protein:CARD9

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.03ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Caspase Recruitment Domain-Containing Protein 9

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9H257

MASS(Da):62,241

GeneID:64170

Synonyms:CARD 9;CARD9;Caspase recruitment domain-containing protein 9;hCARD9

Gene names:CARD9

Standard solution:2400ng/L