Human Caspase 14, CASP14 ELISA Kit

SKU: E2252Hu

Size:96 Tests-1 Kit

Background:Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed: 15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed: 16854378, PubMed: 19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed: 25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed: 24743736).

Research_area:Others

Applications:ELISA

Target_protein:CASP14

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.33ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Caspase 14

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P31944

MASS(Da):27,680

GeneID:23581

Synonyms:CASP 14;CASP14;CASP-14;Caspase-14;Caspase-14 subunit p10, mature form;Caspase-14 subunit p17, mature form;Caspase-14 subunit p20, intermediate form;Caspase-14 subunit p8, intermediate form

Gene names:CASP14

Standard solution:8000ng/L