Human Cancer/Testis Antigen 1, CTAG1A ELISA Kit

SKU: E6592Hu

Size:96 Tests-1 Kit

Background:Cancer/testis antigen 1 also known as LAGE2 or LAGE2B is a protein that in humans is encoded by the CTAG1B gene. It is most often referenced by its alias NY-ESO-1. Cancer/Testis Antigen 1B is a protein belonging to the family of Cancer Testis Antigens (CTA) that are expressed in a variety of malignant tumours at the mRNA and protein levels, but also restricted to testicular germ cells in normal adult tissues. A clone of CTAG gene was originally identified by immunological methods in oesophageal carcinoma using patient serum.[6] The aberrant re-expression of CTAs is induced by molecular mechanisms including DNA demethylation, histone post-translational modification, and microRNA-mediated regulation. The effect of DNA demethylation is evident by the capability of demethylating agents, such as 5-aza-2-deoxycytidine, to induce CTAs re-expression in tumour cells but not in normal epithelial cells.

Research_area:Tags & Cell Markers; Cancer

Applications:ELISA

Target_protein:CTAG1A

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.012ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Cancer/testis antigen 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P78358

MASS(Da):17,992

GeneID:1485;246100

Synonyms:Autoimmunogenic cancer/testis antigen NY-ESO-1;Cancer/testis antigen 1;Cancer/testis antigen 6.1;CT6.1;CTAG;CTAG1A;ESO1;L antigen family member 2;LAGE-2;LAGE2A;LAGE2B;NY-ESO-1

Gene names:CTAG1A; CTAG1B

Standard solution:24ng/ml