Human Beta-site APP-cleaving Enzyme 2,BACE2 ELISA KIT

SKU: E0763Hu

Size:96 Tests-1 Kit

Background:Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112, ECO:0000269|PubMed:21907142}.

Research_area:

Applications:ELISA

Target_protein:BACE2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.26ng/L

Detection range:0.5-200ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:beta-site APP-cleaving enzyme 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y5Z0

MASS(Da):56180

GeneID:25825

Synonyms:BACE2 AEPLC ALP56 ASP21 CDA13 UNQ418/PRO852

Gene names:BACE2

Standard solution:240ng/L