Human ANGPTL6 ELISA Kit PicoKine®

SKU: EK1993

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: ANGPTL6

Specificity: Natural and recombinant human ANGPTL6

Background: Angiopoietin-like 6 (ANGPTL6), also known as angiopoietin-related growth factor (AGF), is a secreted 50 kDa protein that contains a coiled-coil domain and a fibrinogen-like domain. It is mapped to 19p13.2. ANGPTL6 is highly expressed in hepatocytes and is detectable in serum. Within the liver, secreted ANGPTL6 inhibits gluconeogenesis and promotes insulin sensitivity and energy expenditure. Circulating ANGPTL6 promotes the chemotaxis of vascular endothelial cells resulting in increased vascular permeability and angiogenesis. An integrin--binding RGD motif located within the fibrinogen--like domain of ANGPTL6, enables it to promote skin wound healing by mediating the adhesion and migration of keratinocytes, fibroblasts, and endothelial cells. Elevated levels of ANGPTL6 in serum are associated with metabolic syndrome, diabetes, and pre-eclampsia. Serum ANGPTL6 levels are also elevated during obesity. ANGPTL6 is reported to promote the survival and expansion of hematopoietic stem cells. ANGPTL6 is produced by several hematopoietic cell types including megakaryocytes, platelets, mast cells, and uterine NK cells. Mature human ANGPTL6 shares 75% sequence identity with both mouse and rat ANGPTL6.

Immunogen: Expression system for standard: CHO; Immunogen sequence: Ala20-Leu470

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Uniprot ID: Q8NI99

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 83854

Protein Name: Angiopoietin-related protein 6

Gene Full Name: angiopoietin like 6

Synonyms: Angiopoietin-like protein 6; Angiopoietin-related growth factor; Angiopoietin-related protein 5; AGF; ARP5; ANGPTL6; UNQ152/PRO178