Human AKR1C4 ELISA Kit PicoKine®

SKU: EK1870

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: AKR1C4

Specificity: Natural and recombinant human AKR1C4

Background: 3α-Hydroxysteroid dehydrogenase (3α-HSD or aldo-keto reductase family 1 member C4) is an enzyme that in humans is encoded by the AKR1C4 gene. It is mapped to 10p15.1. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: M1-Y323

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Reference:

Uniprot ID: P17516

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 1109

Protein Name: Aldo-keto reductase family 1 member C4

Gene Full Name: aldo-keto reductase family 1 member C4

Synonyms: 3 alpha HSD; 3 alpha HSD1; AKR1C4; C11; CDR; CHDR; Chlordecone reductase; DD 4; DD4; Dihydrodiol dehydrogenase 4; HAKRA