Human A disintegrin and metalloproteinase with thrombospondin motifs 5,ADAMTS5 ELISA KIT

SKU: E3557Hu

Size:96 Tests-1 Kit

Background:Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (By similarity). Participates in development of brown adipose tissue and browning of white adipose tissue (By similarity). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection. {ECO:0000250|UniProtKB:Q9R001, ECO:0000269|PubMed:16133547, ECO:0000269|PubMed:18992360}.

Research_area:

Applications:ELISA

Target_protein:ADAMTS5

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.17ng/ml

Detection range:0.38-24ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:ADAM metallopeptidase with thrombospondin type 1 motif 5

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UNA0

MASS(Da):101718

GeneID:11096

Synonyms:ADAMTS5 ADAMTS11 ADMP2

Gene names:ADAMTS5

Standard solution:48ng/ml