Human 6-phosphofructokinase,PFKL ELISA KIT

SKU: E7294Hu

Size:96 Tests-1 Kit

Background:Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). {ECO:0000250|UniProtKB:P12382, ECO:0000255|HAMAP-Rule:MF_03184, ECO:0000269|PubMed:22923583}.

Research_area:

Applications:ELISA

Target_protein:PFKL

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.29ng/ml

Detection range:0.5-200ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:6-phosphofructokinase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P17858

MASS(Da):85018

GeneID:5211

Synonyms:PFKL

Gene names:PFKL

Standard solution:240ng/ml