HSD11B2 Polyclonal Antibody

SKU: E-AB-13311

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: HSD11B2

Target Synonym: 11 beta HSD2;11 beta hydroxysteroid dehydrogenase type 2;11 DH2;11-beta-HSD2;11-beta-hydroxysteroid dehydrogenase type 2;11-DH2;AME;AME1;Corticosteroid 11 beta dehydrogenase isozyme 2;Corticosteroid 11-beta-dehydrogenase isozyme 2;DHI2;HSD11B2;HSD11K;HSD2;Hydroxysteroid 11 beta dehydrogenase 2;Hydroxysteroid 11 beta dehydrogenase isoenzyme 2;NAD dependent 11 beta hydroxysteroid dehydrogenase;NAD-dependent 11-beta-hydroxysteroid dehydrogenase;SDR9C3;Short chain dehydrogenase/reductase family 9C;member 3

Research Areas: Cancer;Cell Biology;Cardiovascular;Metabolism;Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P80365

Accession:

Background: There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor.

Concentration: 0.6 mg/mL

Immunogen: Synthetic peptide of human HSD11B2

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: IHC 1:50-1:200

Calculated MW:

ObservedMW: