HPGD/15-PGDH Monoclonal Antibody

SKU: AN200014P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:HPGD

Target Synonym:PGDH;SDR36C;PGDH1;SDR36C1;HPGD;15 hydroxyprostaglandin dehydrogenase [NAD+];15 PGDH;15-Hydroxyprostaglandin Dehydrogenase [NAD(+)];15-hydroxyprostaglandin dehydrogenase [NAD+];15PGDH;15-PGDH;Hydroxyprostaglandin dehydrogenase 15 (NAD);NAD+ dependent 15 hydroxyprostaglandin dehydrogenase;OTTHUMP00000218960;OTTHUMP00000219016;OTTHUMP00000219018;PHOAR1;Prostaglandin dehydrogenase 1;Short chain dehydrogenase/reductase family 36C member 1

Research Areas:Immunology;Signal Transduction

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:WB

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:7F10

UNIProt ID:P15428

Accession:

Background:15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone, and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoarthropathy autosomal recessive (PHOAR), cranio-osteoarthropathy (COA), and isolated congenital nail clubbing.

Concentration:1 mg/mL

Immunogen:Recombinant Human HPGD / 15-PGDH protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:1000;

Calculated MW:29 kDa

ObservedMW:29 kDa