HNRNPK antibody , Cat. # FNab03955

SKU: FNab03955

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction(By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21(lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.

Immunogen:heterogeneous nuclear ribonucleoprotein K

Synonyms:CSBP, hnRNP K, HNRNPK, HNRPK, TUNP

Observed MW:51 kDa

Uniprot ID:P61978

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IHC, IF, FC, IP

Recommended dilution:WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:10-1:100

Gene ID:3190

Research Area:Neuroscience, Signal Transduction, Metabolism, Epigenetics