HM13 Antibody, FITC conjugated - Cat. #: CSB-PA851544LC01HU

SKU: CSB-PA851544LC01HU

Size :50ug

Clone Number:

Aliases:dJ324O17.1 antibody; H13 antibody; hIMP1 antibody; Histocompatibility (minor) 13 antibody; HM13 antibody; HM13_HUMAN antibody; IMP-1 antibody; IMP1 antibody; IMPAS antibody; IMPAS-1 antibody; Intramembrane protease 1 antibody; Intramembrane protease antibody; Minor histocompatibility antigen 13 antibody; Minor histocompatibility antigen H13 antibody; MSTP086 antibody; OTTHUMP00000030527 antibody; OTTHUMP00000030528 antibody; OTTHUMP00000030530 antibody; OTTHUMP00000214528 antibody; Presenilin-like protein 3 antibody; PSENL3 antibody; PSL3 antibody; Signal peptide peptidase antibody; Signal peptide peptidase beta antibody; SPP antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8TCT9

Immunogen:Recombinant Human Minor histocompatibility antigen H13 protein (336-377AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:HM13

Research Areas:Metabolism; Signal transduction